Denise Kandel, PhD., Head of the Department of Epidemiology of Substance Abuse at the New York State Psychiatric Institute, Professor of Sociomedical Sciences and Psychiatry at Columbia University. Major interests: the epidemiology, risk factors, and consequences of drug use, in particular smoking and prescription opioid use; the epidemiology of substance dependence; developmental pathways of problem behaviors in adolescence; the intergenerational transmission of deviance; animal models of epidemiological paradigms.
Current research activities focus on five areas: 1) the epidemiology of prescription opioid use and mortality; 2) the Gateway Hypothesis of drug involvement; 3) the intergenerational effects of parental drug use on child drug behavior and development; 4) epidemiology of post-traumatic stress disorder; 5) animal models of the Gateway Hypothesis.
Research
The epidemiology, risk factors, and consequences of drug use, in particular smoking and prescription opioid use; the epidemiology of substance dependence; developmental pathways of problem behaviors in adolescence; the intergenerational transmission of deviance; animal models of epidemiological paradigms.
Current research activities focus on five areas: 1) the epidemiology of prescription opioid use and mortality; 2) the Gateway Hypothesis of drug involvement; 3) the intergenerational effects of parental drug use on child drug behavior and development; 4) epidemiology of post-traumatic stress disorder; 5) animal models of the Gateway Hypothesis.
Selected Publications
- Kandel DB: Stages and Pathways of Drug Involvement: Examining the Gateway Hypothesis, Cambridge University Press, Cambridge, England, 2002
- Hu M-C, Griesler P, Schaffran C, Kandel DB: Risk and Protective Factors for Nicotine Dependence in Adolescence. J Child Psychol & Psychiatry 2011;52: 1063-1072
- Levine A, Huang YY, Disraldi B, Griffin Jr E, Pollak DD, Xu S, Yin D, Schaffran C, Kandel DB, Kandel ER: Molecular Mechanism for a Gateway Drug: Epigenetic Changes Initiated by Nicotine Prime Gene Expression by Cocaine. Sci Trans Med 2011;3: 107ra109
- Koob G, Kandel DB, Baler RD, Volkow N: Pathophysiology of Addiction, John Wiley & Sons, West Sussex, England, 2015
- Kandel ER, Kandel DB: Shattuck Lecture: A Basis for Nicotine as a Gateway Drug. NEJM 2014;371: 932-943
- Kandel DB, Hu MC, Griesler P, Wall, M: Increases From 2002 to 2015 in Prescription Opioid Overdose Deaths in Combination with Other Substances. Drug & Alc Depend 2017;178: 501-511
- Wall M, Cheslack-Postava K, Hu MC, Feng T, Griesler P, Kandel DB: Nonmedical Prescription Opioids and Pathways of Drug Involvement in the US: Generational Differences. Drug & Alc Depend 2018;182: 103-111
- Griesler PC, Hu MC, Wall MM, Kandel DB: Medical Use and Misuse of Prescription Opioids in the US Population: 2016-2017. Am J Pub Health 2019;109: 1258-1265
- Griesler PC, Hu MC, Wall MM, Kandel DB: Nonmedical Prescription Opioid Use by Parents and Adolescents in the US. Pediatrics 2019;143: e20182354
For a complete list of publications, please visit PubMed.gov(link is external and opens in a new window)