Quiz 3

Instructions:

Read each question carefully before answering.
For Multiple Choice Questions, select the best answer by choosing A, B, C, or D.
For True/False Questions, indicate whether the statement is True or False.
For Fill-in-the-Blank Questions, write the most accurate word or phrase to complete the sentence.
Take your time to reflect on the concepts and review your answers if needed.

Nanoparticle-Based Drug Delivery Systems

What is the primary advantage of nanoparticle-based drug delivery systems? *

Increasing the size of therapeutic drugs

Reducing drug bioavailability

Targeting specific sites and improving therapeutic efficacy

Eliminating the need for patient monitoring

How do nanoparticles improve drug delivery in neurosurgery? *

By bypassing the circulatory system

By crossing the blood-brain barrier

By preventing drug absorption in tissues

By stopping tumor growth without targeting

Examples of Nanoparticle-Based Drug Delivery Systems

Doxil is a liposomal formulation of doxorubicin designed to reduce toxicity to healthy tissues. *

True

False

PLGA nanoparticles are non-biodegradable polymers that release drugs instantly at the target site. *

True

False

__________ is an albumin-bound formulation of paclitaxel used to improve drug delivery to tumor sites in brain and breast cancers. *

is an albumin-bound formulation of paclitaxel used to improve drug delivery to tumor sites in brain and breast cancers.

Nanoparticles encapsulating __________ are used to treat glioblastoma and prevent transplant rejection in brain surgeries. *

Nanoparticles encapsulating are used to treat glioblastoma and prevent transplant rejection in brain surgeries.

What is a key benefit of PLGA nanoparticles in drug delivery? *

Instant drug release at the target site

Sustained release and reduced inflammation

High toxicity to surrounding tissues

Enhanced imaging capabilities during surgery

PLGA nanoparticles are particularly useful in spinal cord injury because: *

They deliver chemotherapy drugs directly to tumors.

They promote sustained release of drugs and reduce inflammation.

They prevent infections at surgical sites.

They bypass the blood-brain barrier entirely.

Nanoparticles encapsulating sirolimus are used to: *

Replace damaged neurons in the brain

Prevent transplant rejection and treat brain tumors

Create a barrier to prevent drug absorption

Deliver anti-inflammatory drugs to the spinal cord

Real-World Examples and Case Studies

In a clinical trial, PLGA nanoparticles failed to reduce inflammation and promote nerve regeneration in spinal cord injuries. *

True

False

__________ nanoparticles have been used to deliver anti-inflammatory drugs to spinal cord injuries, improving motor function in animal models. *

nanoparticles have been used to deliver anti-inflammatory drugs to spinal cord injuries, improving motor function in animal models.

Gene therapies using nanoparticles can cross the blood-brain barrier to deliver genetic material directly to affected areas in Alzheimer’s patients. *

True

False

Nanoparticle-based sirolimus delivery systems show potential in reducing __________ growth and improving outcomes in brain tumor treatments. *

Nanoparticle-based sirolimus delivery systems show potential in reducing growth and improving outcomes in brain tumor treatments.

Mechanisms and Benefits of Delivery Systems

How do PLGA nanoparticles benefit patients with neurodegenerative diseases? *

By releasing chemotherapy drugs rapidly

By reducing inflammation through sustained drug release

By preventing blood flow to the brain

By targeting only cancer cells

Why are liposomal drug formulations, like Doxil, effective in glioblastoma treatment? *

They destroy healthy tissues to clear paths for the drug.

They improve bioavailability and concentrate the drug at the tumor site.

They prevent drug absorption by the tumor.

They bypass the bloodstream entirely.

Abraxane is an example of a nanoparticle-based drug delivery system tested in both brain and breast cancer therapies. *

True

False

Nanoparticles in gene therapy for Alzheimer’s disease target the bloodstream rather than brain cells. *

True

False